Your Cancer Patient Responded to Immunotherapy. Then…

Your Cancer Patient Responded to Immunotherapy. Then stopped. You increased the dose. Tried a different combination. Changed the protocol. Still nothing. You have seen this. Every oncologist has. A new study published in Nature just found out why this happens and it changes everything about how we think about T cell exhaustion in cancer. The discovery: a molecule called SLAMF6. SLAMF6 is found on the surface of immune cells and works as a hidden brake: weakening the body's cancer fighting T cells and leaving them exhausted over time. What makes this different from every other immune checkpoint we know? Most known immune checkpoints require interaction with tumour cel