Not All "Same" Heart Failure Is the Same, New Research…

Not All "Same" Heart Failure Is the Same, New Research Uncovers Two Distinct Metabolic Subtypes Dilated cardiomyopathy is a form of heart failure where the heart's main pumping chamber becomes enlarged and weakened. Two patients can carry the exact same diagnosis, the same severity of disease, and yet have entirely different underlying biology driving their condition. A new study published in Circulation: Genomic and Precision Medicine may explain part of why treatments targeting heart metabolism have had such inconsistent success because doctors may actually be treating two different diseases under one name. The heart is one of the body's most energy-hungry organs, and how it produces that energy shifts noticeably in heart failure. But researchers have long suspected that this metabolic shift doesn't look the same in every patient, it may depend on what originally caused their condition, whether genetic, viral, or otherwise unexplained. Rather than relying on expensive, invasive metabolic testing, the team developed a computational method that can estimate detailed metabolic activity directly from standard gene expression data — data that's far more widely available in existing research. They applied this method to heart tissue samples fro