Lower IgM Antibody Levels May Be Linked to Advanced…

Lower IgM Antibody Levels May Be Linked to Advanced Age-Related Macular Degeneration Age-related macular degeneration (AMD) is one of the leading causes of vision loss in older adults. Increasing evidence also suggests that AMD and cardiovascular disease (CVD) may share common biological pathways, particularly those involving inflammation and oxidative stress. A recent study published in Arteriosclerosis, Thrombosis, and Vascular Biology investigated whether naturally occurring IgM antibodies against oxidation-specific epitopes (OSE-IgM) are associated with the risk of AMD. Researchers analyzed data from the AugUR (Age-Related Diseases: Understanding Genetic and Nongenetic Influences) study in Germany. The study included 2,264 adults aged 70–95 years, comprising: 627 participants with AMD 1,637 participants without AMD The investigators measured circulating IgM antibodies against three oxidation-specific targets: P