How Should Amyloid PET Scans Be Interpreted? Large…

How Should Amyloid PET Scans Be Interpreted? Large Meta-Analysis Defines New Centiloid Thresholds Amyloid positron emission tomography (PET) imaging plays an increasingly important role in diagnosing Alzheimer's disease, determining eligibility for anti-amyloid therapies, and supporting clinical decision-making. However, one long-standing challenge has been determining what level of amyloid should be considered "positive." A large international meta-analysis published in JAMA has now proposed standardized Centiloid thresholds that may improve the interpretation of amyloid PET scans across both research and clinical practice. Researchers analyzed data from 49,227 participants across 53 studies conducted in 15 countries, making it one of the largest analyses of amyloid PET imaging to date. What Is the Centiloid Scale? The Centiloid scale is a standardized method used to quantify amyloid burden on PET scans regardless of the imaging tracer or processing method. * 0 Centiloids represents the average amyloid level in healthy young adults. * 100 Centiloids represents the average amyloid burden