Do Multiple Myeloma Patients Really Need Indefinite…

Do Multiple Myeloma Patients Really Need Indefinite Maintenance Therapy? A Major Trial Says No For patients with newly diagnosed multiple myeloma, standard practice has long involved lenalidomide maintenance therapy continued indefinitely, essentially for as long as the disease remains controlled. But how long is actually necessary has remained genuinely unclear. A large phase 3 trial published in the New England Journal of Medicine now offers a clear answer. Researchers enrolled 516 patients with standard risk, newly diagnosed multiple myeloma, specifically those not undergoing upfront stem cell transplantation. After initial induction treatment, patients were randomly assigned to either indefinite duration lenalidomide, continuing until disease progression, or fixed duration lenalidomide, stopped after two years. Patients were followed for a median of 86 months, over seven years, making this one of the lon